C Street is a major street in historic downtown Marysville. From south to north, significant places on C Street include Cakes by Request, Nakagawa Company, the Marysville Post Office, Biggs United Methodist Church, and St. Joseph Catholic Church.

In 1858, the California State Fair was held in Marysville, in the area bounded by B Street, C Street, 5th Street, and 6th Street.